A Faculty Member from the Chemistry Department Publishes a Scientific Paper
Asst. Prof. Dr. Sawsan Khudair Abbas from the Chemistry Department published a scientific paper titled: Synthesis and biological evaluation of new 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazole derivatives as antioxidant and antimicrobial agents.
Preparation and biological evaluation of new 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazole derivatives as antioxidant and antimicrobial agents.
Published in the Chemical Data Collection, indexed in Scopus (Q3).
The research aimed to study imidazole derivatives and their wide-ranging applications in pharmaceutical chemistry, where they are studied as biologically active compounds. Their properties include antidepressant, anti-inflammatory, antiviral, antimicrobial, and antifungal activity. Two imidazole derivatives (1a-1f) and (a-2f2) were synthesized using a simple, versatile, and efficient protocol with aspartic acid as a catalyst under reversible conditions.
The results were good to excellent. The structures of all synthesized compounds were characterized using infrared spectroscopy, Fourier transform spectroscopy, nuclear magnetic resonance (NMR) (1H and 13C), and elemental analysis. All compounds were screened for their potential as antioxidant and antimicrobial agents.
The study found that the evaluated compounds (1c, 1d, 2c, and 2d) exhibited a dominant IC50 value in the antioxidant assay compared to ascorbic acid as a standard drug. Antibacterial and antifungal activity tests indicated that all compounds showed good to excellent activity compared to standard drugs. Therefore, this suggests their potential for developing novel therapeutic drugs.
