The College of Education for Pure Sciences Discusses a Master’s Thesis on a Molecular and Physiological Study of Multiple Sclerosis.
The Department of Biology at the College of Education for Pure Sciences, University of Kerbala, discussed a Master’s thesis entitled “A Molecular and Physiological Study of Multiple Sclerosis in a Sample of Patients in the Holy Kerbala Governorate”
By student Huda Adnan Kadhim
Supervised by Prof. Dr. Yasmin Khudair Khalaf
The study aimed to investigate genetic and physiological diagnostic criteria by examining the single nucleotide polymorphisms rs3135388 and rs9271366 in the progression of multiple sclerosis in a sample of patients with the disease, compared to healthy individuals. It also conducted a physiological study, detecting glial fibroblast levels in serum samples from patients with multiple sclerosis compared to healthy individuals, to determine the course and progression of the disease. Finally, the study investigated the relationship between the allele frequency of the rs3135388 and rs9271366 genes and the serum glial fibroblast profile of patients with the disease compared to healthy individuals.
The study concluded that there is a trend suggesting that patients with the GG genotype may have greater multiple sclerosis activity, as evidenced by elevated GFAP levels. However, since P = 0.59, the result is not statistically significant. Further studies with larger samples may help determine whether the GG genotype is indeed associated with increased GFAP. In the control group, the rs9271366 genotype did not significantly affect GFAP levels.
The study recommended further molecular research on genetic markers, such as genotypes, in a larger sample of patients to assess their impact and association with the disease.
It also recommended studying biomarkers of disease activity, as these markers can differentiate between patients with intermittent relapse and those with secondary progression.
