A Chemistry Department Faculty Member Publishes a Scientific Paper
Assistant Professor Dr. Sawsan Khudair Abbas from the Chemistry Department published a scientific paper titled:
Synthesis, Antibacterial Evaluation, and Molecular Docking of 2,4,5-Tri-imidazole Derivatives
Preparation and Evaluation of the Antibacterial Activity and Molecular Docking of 2,4,5-Triimidazole Derivatives
in the Moroccan Journal of Chemistry
Indexed in Q3
The research aimed to prepare high-volume tri-substituted imidazole by reacting one of its components with aromatic aldehydes, benzyl, and ammonium acetate, catalyzed by glacial acetic acid using microwave irradiation. This method was compared to traditional methods, employing a basic preparation process and a simple purification technique.
The research presented an easy, clean, rapid, efficient, and inexpensive method for preparing organic compounds, which has become known as a tool in green chemistry. Using this method, chemical reactions can be accelerated from hours to minutes. All synthesized compounds were studied using a variety of spectroscopic methods, including Fourier transform infrared spectroscopy, monovalent nuclear magnetic resonance, trivalent nuclear magnetic resonance, and trivalent carbon spectroscopy.
The study found that compound 4b exhibited good molecular docking with Staphylococcus aureus, compound 4c with Escherichia coli, and compound 4c with Bacillus subtilis, exhibiting the lowest binding energies in the active site regions of all targets. These results suggest that the newly synthesized compounds have promising inhibitory activity and can be used as antibacterial agents.
