The College of Education for Pure Sciences Discusses a Master’s Thesis on the Effect of Some Epilepsy Medications on Certain Brain Regions in Male Albino Rats.
The College of Education for Pure Sciences Discusses a Master’s Thesis on the Effect of Some Epilepsy Medications on Certain Brain Regions in Male Albino Rats.
The College of Education for Pure Sciences Discusses a Master’s Thesis on the Effect of Some Epilepsy Medications on Certain Brain Regions in Male Albino Rats.
The Department of Biology at the College of Education for Pure Sciences, University of Kerbala, discussed a Master’s thesis entitled “The Effect of Some Epilepsy Medications on Certain Brain Regions in Male Albino Rats: A Histological Study.”
The thesis was presented by student Murtadha Ahmed Obaid Al-Ardawi, under the supervision of Prof. Dr. Sinaa Jabouri Mohammed Al-Bazi.
The study aimed to determine the protective effect of an alcoholic extract of grape fruit in reducing autism-like behavior in male albino rats. This was achieved by assessing the animals’ weight and social behavior using the three-chamber test, and by estimating the levels of certain oxidative stress markers in hippocampal tissue, namely oxidants such as malondialdehyde and antioxidants such as glutathione and superoxide dismutase.
The study concluded that valproic acid, administered at a dose of 450 mg/kg prenatally, can cause neurological damage by reducing the social and behavioral abilities of animals treated with valproic acid. Specifically, a decrease in the social preference index compared to the control group was observed, confirming the drug’s detrimental behavioral effect.
The study recommended further histological studies to elucidate the therapeutic effect of alcoholic grape fruit extract in experimental animals exposed to valproic acid postnatally. It also recommended investigating the effect of alcoholic grape fruit extract on microglia using more specific markers.
