The Department of Life Sciences discusses a doctoral thesis entitled (genetic polymorphisms of the pon1 gene in type 2 diabetes patients in Karbala governorate)
The Department of Life Sciences discusses a doctoral thesis entitled (genetic polymorphisms of the pon1 gene in type 2 diabetes patients in Karbala governorate)
The Department of Life Sciences discusses a doctoral thesis entitled (genetic polymorphisms of the pon1 gene in type 2 diabetes patients in Karbala governorate)
The Department of Life Sciences, College of Education for Pure Sciences / University of Karbala, discussed a doctoral thesis tagged (the genetic polymorphisms of the pon1 gene in type 2 diabetes patients in Karbala governorate), by student Radhya Najm Abdul-Saadi. and under the supervision of Prof.Dr Yasmine Khudair Khalaf. on Thursday 27/8/2020. and this was done by using the FCC electronic platform to communicate with the members of the committee, and the aim of the discussion was to study the relationship between some polymorphisms in the coding region of the PON1 gene and its effect on the level of the PON1 enzyme, and to study the relationship between Laboratory criteria, risk factors for diabetics, genotypes of studied polymorphisms of the gene, determination of the rate of recurrence of genotypes, and alleles for both polymorphisms in diabetic patients and the control group, and the use of advanced molecular methods to identify some types of polymorphisms in diabetics in Karbala governorate, and it is worth noting The study was able to register 20 new sequences in the ncbi global gene bank of the PON1 gene. From the findings of the study, it was found that the effect of some risk factors such as age, sex, smoking, high blood pressure, heart disease, and family history of the disease in increasing the risk of developing type 2 diabetes, high levels of TG triglycerides, very low density lipoproteins (VLDL), and a decrease in the concentration of the enzyme PON1 in Blood serum in diabetic patients, detection of one SNP A67G in plot 151bp of polymorphism Q192R, detection of two new SNPs in plot 38bp which are A210C, A212C and intronic SNPS, the discussion came out with several recommendations, including: Addition of enzyme activity measurement PON1 and its focus to other conventional diabetes analyzes to determine the effect of physiological activity of the enzyme on preventing complications of diabetes in patients, studying the polymorphisms Q192R and L55M in large population groups to verify the occurrence of genotypes and alleles in patients with diabetes, and other diseases and different molecular methods, studying other types of The formalities, whether in the coding region, or the promoter region, which have a relationship with the formalities. Under study in the effect of the activity of the PON1 enzyme and its concentration, the study of the phenotypes of the PON1 gene in other diseases related to antioxidant activity, conducting type II diabetes tests for family members of people with a family history of the disease, and the student obtained a doctorate.
