The College of Education for Pure Sciences Discusses a Master’s Thesis on an Immunological, Biochemical, and Hematological Study of a Sample of Patients with Cutaneous Leishmaniasis.
The Department of Life Sciences at the College of Education for Pure Sciences, University of Karbala, discussed a Master’s thesis entitled “An Immunological, Biochemical, and Hematological Study of a Sample of Patients with Cutaneous Leishmaniasis.”
The thesis was presented by student Taghreed Abdul Wahab Saleh, under the supervision of Professor Dr. Kawthar Abdul Hussein Mahdi.
The study aimed to evaluate several immunological variables, including measuring the levels of certain cellular and chemokinetic processes. It also assessed the levels of oxidants and measured certain hematological parameters, comparing them to control groups and other dermatological diseases.
The study concluded that the Th2 immune response is dominant in patients with cutaneous leishmaniasis, promoting chronic inflammation and reducing the effectiveness of cellular immunity. Furthermore, the study found lower levels of oxidative stress, such as MDA, in cutaneous leishmaniasis compared to other dermatological diseases, suggesting defensive mechanisms of the parasite. Limited hematological changes were observed, primarily a decrease in white blood cell and neutrophil counts, with minor differences in platelet count, but no significant impact on red blood cell count.
The study recommended longitudinal studies to confirm the efficacy of markers such as GSH and IL-18 in the early diagnosis and clinical follow-up of patients with cutaneous leishmaniasis.
The study also recommended developing novel therapies that enhance the Th1 immune response to counteract Th2 dominance and improve recovery from infection.
It further recommended integrating immunological and oxidative markers into clinical treatment protocols to improve health outcomes and reduce complications.
