The Department of Chemistry Discusses a Master’s Thesis on the Preparation of a New Nanopolymer and the Study of its Effect on some Biochemical Parameters in White Male Rats

Discussion of a Master’s Thesis

The Department of Chemistry at the College of Education for Pure Sciences discussed the master’s thesis for the student (Ayat Hussein Azab) under the supervision of (Prof. Dr. Muhammad Nazem Bahgat), and the second supervisor (Asst.Prof.Dr. Alaa Hussein Mahdi) about her thesis entitled (Preparation of a new nanopolymer and a study Its effect on some biochemical parameters in male white rats. The aim of the study was:
1. Preparation of a new nanopolymer, and its diagnosis using techniques (FT-IR, HNMR, XRD, AFM, TEM)
2. Covalent bonding of non-steroidal drugs with the nanopolymer prepared in paragraph 1 above through esterification reaction, and characterization of the product using (FT-IR, HNMR) spectroscopy.
3. Measurement of biochemical parameters in the serum on a sample of white male rats using the nanopolymer prepared in paragraph 1.2 above, which includes:-
a) Creatinine and Urea
b) Liver enzymes such as alkaline phosphatase (ALP) and the two enzymes that transport alanine transaminase (ALT).
4. Knowing the histological changes of liver and kidney tissue in male albino rats using the nanopolymer prepared in paragraph 1.2 above.
* The most important conclusions:
1. The new nanopolymer was synthesized and characterized using FT-IR, 1 HNMR, AFM, XRD, and . TEM technologies.
2. Polymeric nano drugs were synthesized and characterized using FT-IR and 1HNMR. techniques
3. The use of mefenamic acid, nano-mefenamic acid, naproxen, and nano-naproxen causes an increase in the levels of liver enzymes, including the enzyme aspartate aminotransferase (AST).
4. The use of the two drugs and the drugs loaded on the nano induced some changes in the tissues of the liver and kidneys.
After extensive scientific discussion and listening to the student’s defense of her thesis, her research method, and her use of sources and references, the thesis was approved with honors. Congratulations to the student, her supervisors, the Department of Chemistry, and the College of Education for Pure Sciences for this great achievement, and God Almighty grants success.