A Scientific Article
The Associate Dean for Scientific Affairs, Prof. Dr. (Mohammed Nazem Bahjat) obtained the acceptance to publish a scientific article tagged with the title (Preparation of new nano pharmaceutical hydrogels with a three-dimensional network and its use for drug delivery) by the Scientific Articles Committee at the Presidency of Karbala University after the article fulfilled all publication conditions. Prof. Dr. (Mohammed Nazim Bahgat) mentioned that over the past few decades, the hydrogel nanopolymer has achieved great development due to the development in the technical field, which led to its use in many biomedical applications, including the controlled release of drugs, as there are many researches on hydrogel nano polymers, which are designed on the basis of protein delivery, due to the increasing medical and pharmaceutical needs, where mathematical modeling plays an important role in facilitating the design of the hydrogel network by determining the basic parameters and molecule release mechanisms. Nanopolymer hydrogels are a three-dimensional network that can absorb water and biological fluids. It has been used as useful therapeutic agents, and as a carrier material for a selection of small molecules of proteins, genetic materials, or other drugs and plays a vital role in drug delivery, so choosing nanopolymer has an important role in the manufacture and delivery of drugs. The use of nanopolymers in medicine has witnessed an important development in the last three decades. Polymers as biological materials have found some important applications, such as the manufacture of artificial organs, tissue engineering, components of medical and dental equipment, as well as the use of hydrogel polymeric nanomaterials as distribution agents to treat various disease conditions, and they were also used for drug delivery. To specific regions or targets to reduce toxicity and enhance selectivity for specific agents against tumors, and to restrict molecules and small molecular components with low molecular weights in the intestinal region such as bile acids, phosphates, and iron, the reason for the success of hydrogel nanopolymers in applications is due to their compatibility with biological methods and the strength of their soft nature, Less toxic, more selective and not absorbed symmetrically in the intestinal area, this made them have desirable benefits. Delivery of medication in a certain period, especially Do not procrastinate with it, as this feature gives the continuity of the high benefit of the drug and in a rapid metabolic manner and removes the unwanted drug residues from the living body, as this process is related to the body’s need for the drug and not by giving the patient medication in the form of continuous doses to benefit from it at the moment required by the body or the affected part. These nano-hydrogels can protect the protein drug from the effect of the acidic function of the stomach and then release it into the alkaline medium of the intestine by encapsulating the protein drug with the hydrogel nanonetwork, where it compresses the proteins and makes them smaller so that these can cross the cell membranes more quickly, and after these carriers are accomplished Hydrogel work is to deliver the drug to the inside of the cell until it breaks down and allows the protein to return to its original form and its normal activity and is not anti-protein or the host body.
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