PhD Dissertation Discussion
The Department of Life Sciences, College of Education for Pure Sciences/University of Karbala, discussed the doctoral thesis tagged (physiological and biochemical study of acute lymphoblastic leukemia in children without a family history of the disease before and after chemotherapy in central Iraq), by the student (Zainab Tawfeeq Hassan Al-Jubouri).
The aim of this thesis was to study and assess the levels of (Galectin-9), mannose-binding lectin (MBL), as well as several routine hematological information in addition to assessing the levels of the oxidative stress index involving nitric oxide (NO). In addition, the study included the determination of a number of antioxidant parameters (T-GSH and GSSG). And studying the levels of some hormones Erythropoietin (EPO), Serotonin (ST), Parathyroid (PTH), as well as total protein (TP), albumin (Alb), and ferritin (FT), in addition to evaluating the levels of some vitamins including vit D3 and vitB12 and some elements Trace elements such as zinc, cobalt, iron, manganese and copper, as well as some other electrolytes such as calcium, magnesium, sodium, chlorine and potassium.
The study concluded that Gal-9, MBL, EPO, and FT could be important and excellent diagnostic tools for the prediction and diagnosis of children with acute lymphoblastic leukemia during childhood. Some patients’ responses to the chemotherapy protocol were achieved as responses to certain physiological and biochemical blood parameters. After follow-up and doses of chemotherapy, differences in the levels of the oxidative stress biomarkers NO and the antioxidant molecules T-GSH and GSSG indicate severe oxidative stress associated with pediatric acute lymphocytic leukemia.
The researcher recommended studying the LGALS9 gene polymorphism of the gene responsible for encoding lactin-9 in children with acute lymphocytic leukemia and evaluating the levels of lactin-9 and some other types of proteins and interleukins in sera samples of other patients with other hematological cancers and comparing them with the results of diseases Solid carcinogenesis: Monitor oxidative stress levels in acute leukemia patients for advanced treatment stages. The student received an honors grade.
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