A Lecturer from the Department of Chemistry Publishes a Scientific Research Paper on the Synthesis of Some Pharmaceutical Prodrug Compounds Using the Maleimide Derivatives Method

Publishing a Scientific Research

Dr. Ammar Abdul Hussein Al-Karawi from the Department of Chemistry published a scientific paper titled “Synthesis of Some Prodrug Compounds Based on Maleimide Derivatives Method” in the Journal of the Chemical Society of Pakistan.
The research aimed to prepare four different prodrug derivatives by linking different antibiotics (ampicillin, amoxicillin, ceftriaxone, and cefotaxime) to 4-maleimidobenzoic acid (4-(2,5-dihydro-1H-pyrrole-1-yl) benzoic acid), which is first converted to 4-(2,5-dihydro-1H-pyrrole-1-yl) benzoyl chloride in the presence of SOCl2 to form four maleimide derivatives [5a-d]. These derivatives were characterized using Fourier transform infrared, nuclear magnetic resonance, three-dimensional nuclear magnetic resonance, nuclear magnetic resonance, and C.H.N.S. tests. The research also included a study of their antibacterial activity against E. coli and Staphylococcus aureus. Their anticancer activities were also investigated, and their ability to reduce cell viability in the MCF7 human breast cancer cell line was determined. The study concluded that the compounds produced in this study have a promising activity profile in terms of slowing the growth of both cancer cells and selected bacteria.