A Lecturer from the Department of Chemistry Publishes a Scientific Research Paper on the Synthesis and Antibacterial Activity of Some New Drug-loaded Polymaleimide Derivatives

Publishing a Scientific Research Paper

Dr. Ammar Abdul Hussein Al-Karaawi from the Department of Chemistry published a scientific paper titled “Synthesis and Antibacterial Activity of Some New Drug-Loaded Polymaleimide Derivatives” in the Cognizance Journal of Multidisciplinary Studies.
The research aimed to synthesize new polymers via the free radical polymerization of three different drug-substituted maleimides in THF using azobisibbutyronitrile (AIBN) as an initiator in a nitrogen atmosphere at 65°C for 18 hours. The maleimide monomers were synthesized by coupling 4-maleimidobenzoic acid with the amino group of three drugs (mesalzine, theophylline, and 4-aminoantipyrine).
The research also involved the polymerization of these monomers to yield three polymers (e-f). The synthesized polymers were characterized using H-NMR and FT-IR spectroscopy techniques. Drug release and swelling rates were examined at different acidic and basic pH levels. The intrinsic viscosity of these polymers was evaluated at 25°C using an Ostwald viscometer and based on their solubility. The study evaluated the physical and chemical properties of all produced monomers and the antibacterial activity of the derivatives against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).