Ph.D. Dissertation Discussion

The Department of biology at the College of Education for Pure Sciences discussed the doctoral dissertation of the student (Maysa Taqi Abdul Hassan Al-Khazali) under the supervision of (Asst. Prof. Dr. Ban Musa Hassan) and the second supervisor (Asst. Prof. Dr. Salam Ahmed Abdel Ibrahim). The dissertation entitled (Study of the inhibitory effect of sage plant extract and its nanocomposite against some types of Candida in children in Karbala Governorate)
The dissertation aimed to find a safe and effective alternative for the treatment of oral candidiasis, represented by sage plant, and to test the efficiency of some of its active components against the candida causing the disease, in addition to preparing an effective nano-plant extract and comparing its inhibitory efficiency with the crude extract of the plant against isolated species.

* The Most Important Conclusions:

The presence of different types of candida that contribute to the occurrence of oral candidiasis, the most frequent of which was Candida Albicans with the emergence of two isolates of Candida Albicans and one isolate of C. Lusitaniae resistant to amphotericin and one isolate of C. dubliniensis resistant to Flucytosine.
The raw aqueous and alcoholic extract of the leaves of the sage plant contains saponins, tannins, carbohydrates, glycosides, resins, and flavonoids.
– The superiority of the crude alcoholic extract of the leaves of the sage plant in the inhibition of all isolated sensitive Candida species.
Separating 18 active compounds and purifying them from the alcoholic extract using Prep.HPLC, and identifying three compounds, namely, Caffeic acid, and Ferulic acid Kaempferol, which showed inhibitory activity against all types of Candida sensitive to amphotericin.
The efficiency of the prepared hybrid nano-plant compound in inhibiting Candida species.
After extensive scientific discussion and listening to the student’s defense of her thesis, her research method, and her use of sources and references, the thesis was approved with distinction. Congratulations to the student, her supervisors, and the College of Education for Pure Sciences for this scientific achievement.