Discussion of a Master’s Thesis

The Department of Chemistry in the College of Education for Pure Sciences discussed the master’s thesis for the student (Maryam Ali Abdel Samad) under the supervision of (Prof. Hamida Idan Salman) respected and the second supervisor (Prof. Muthanna Saleh Mashkor) for her thesis entitled ((Thermodynamic And Kinetic For) Spectrophotometric Determination Of some Anti-Viral Drugs). The aim of the message was:
1. Finding an easy, fast, and inexpensive spectrophotometric method for the pure determination of some antiviral drugs such as hydroxychloroquine and lopinavir.
2. Studying the best analytical conditions, including (reagent concentration, Ph, temperature, time, etc.).
3. Study of thermodynamic functions such as entropy, enthalpy, and free compressive energy.
4. Study of kinetic functions, order, and rate of reaction, in addition to the study of activation energy.
* The most important conclusions:
1. The analytical method was fast, easy, and inexpensive for the spectrophotometric determination of HCQ and LPV drugs, as it had high accuracy and precision.
2. The best oxidizing agent was potassium periodate which gave high drug absorption with 2,4-Dinitro phenyl hydrazine reagent in the alkaline medium.
3. The method was selective for the determination of drugs with the reagent in the presence of different interfaces
4. This method contains a stable product, azo dye, after some time
5. The method was spontaneous, endothermic, and more systematic for both drugs.
6. The reaction of the reagent with drugs in the presence of the oxidizing agent potassium periodate is a pseudo-second-order reaction.
After extensive scientific discussion and listening to the student’s defense of her thesis, her research method, and her use of sources and references, the thesis was approved with honors. Congratulations to the student, her supervisors, the Department of Chemistry, and the College of Education for Pure Sciences for this great achievement, and God Almighty grants success.