Instructor (Prof. Dr. Hiam Abdel Reda) from the Department of biology published a paper entitled (Validations of Prognostic Scoring Systems in Iraqi (Patients with Chronic Myeloid Leukemia in Single Center), which was published in the International Journal of Pharmaceutical Quality Assurance). The research concluded that chronic myelogenous leukemia, also known as chronic myelogenous leukemia (CML) is a slow myeloproliferative neoplasm. The objectives of this study are to investigate the effectiveness of Sokal, EUR, EUTOS, and ELTS scoring systems in predicting the outcome of patients with CML. Chronic myeloid leukemia (CML-CP) treated with tyrosine kinase inhibitors (TKIs) in Karbala city in Iraq and assessment of characteristics of CML patients and their molecular response. Seventy-one CML patients were recruited for this retrospective and prospective study from April 2017 to March 2018, Al-Hussein Medical City Hematology Oncology Center in Karbala, Iraq Assessed from a clinical point of view, scoring systems indicate the most reliable clinical diagnostic methods for evaluating leukemia patients Chronic myelomeningocele. SoCal, EURO, YOTOS, and ELTS scoring systems are effective in predicting early response to treatment.