The Department of biology at the College of Education for Pure Sciences discussed the master’s thesis for student (Noor Majed Hussein Al-Shaabi) entitled (Evaluation of the protective role of aqueous extract of Ginkgo biloba leaves on the functional and tissue damage of nervous tissue resulting from aluminum chloride in male white rats), under the supervision of Prof. Assistant Dr. (Heba Alwan Abdel Salam). The current study aimed to: 1- Studying the effect of AlCl3 on some enzyme parameters (Acetylcholine esterase (AchE), Neuronal Mitochondrial ATPase, Cytochrome C Oxidase. 2- Studying the effect of AlCl3 on some hormones (cortisol, ACTH, and GH). 3- Studying the protective role of the aqueous extract of Ginkgo biloba against AlCl3-induced oxidative stress. 4- Study of tissue damage caused by AlCl3 in brain tissue, cerebellum, and spinal cord. While it was concluded from the current study: that oral administration of 10 mg/kg of aluminum chloride AlCl3 led to: a- A change in the rate of concentration of the molecular forms of the enzyme acetylcholinesterase (AChE (G1), AChE (G2) b- Significant decrease (P<0.05) in the average concentration of Neuronal Mitochondrial ATPase enzyme. c- Occurrence of oxidative stress and an increase in the level of free radicals as a result of the significant (P < 0.05) increase in the concentration of MDA, Ca +, + Fe. d- An imbalance in the concentration of hormones occurred through a significant increase (P<0.01) in the rate of Cortisol, and ACTH and a significant decrease (P<0.05) in the average GH concentration. e- The occurrence of obvious degenerative changes in the nervous tissue, and the appearance of Aβ-amyloid plaques. Treatment with an effective dose of aqueous extract of the Ginkgo biloba plant significantly reduced the damage to brain tissue, cerebellum, and spinal cord and effectively contributed to restoring biochemical parameters to normal levels. After extensive scientific discussion and listening to the student’s defense of her thesis, her research method, and her use of sources and references, the thesis was approved with honors. Congratulations to the student, her supervisor, the College of Education for Pure Sciences, and the University of Karbala for this achievement, and God Almighty grants success and payment.
