The Department of biology at the College of Education for Pure Sciences, University of Karbala, discussed a master’s thesis entitled (Molecular Study of Patients with Vitiligo in Karbala Governorate), for the student (Karar Abd Ali Jahil), and under the supervision of a Prof. Meet Hassoun Sakban. Where the thesis aims to detect the allelic frequency of the gene Rs1801133 C/T in people with vitiligo and compare it with non-affected (healthy) people using the AREM-PCR technique, and conduct an epidemiological study of vitiligo in Karbala governorate according to (number of infections, age group, marital status The family history of the disease, the location of the infection on the body, smoking, and the presence of chronic diseases), and conducting a physiological study of the blood profile of patients with vitiligo and comparing it with healthy people. The thesis showed that vitiligo constitutes a global incidence rate compared to international standards for disease rates, and vitiligo causes a health problem in Iraq, including the Karbala governorate in particular, due to the high rates of infection in recent years, the epidemic of the disease and its spread to different ages and genders, and its relationship to smoking and chronic diseases. Family history and location of infection. The results of the molecular aspect of the MTHEFR gene showed the emergence of three forms and genotypes in people with vitiligo, as well as in the case of healthy people, and the proportion of the allelic phase (CT) phase was more compared to the control (the healthy people). The researcher recommended educating citizens about the risks related to the disease and how it originated and raising their health awareness, which is one of the ways to reduce and prevent disease, conducting a field epidemiological study on the disease at the level of Iraq and knowing the epidemiology of the disease in Iraq compared to other countries of the world, conducting many studies regarding autoimmunity Acquired immunity, cellular cytokines and its relationship with blood picture groups to prove the physiological reasons for the emergence of the disease, conducting a molecular study to understand the candidate genes for the occurrence of vitiligo in Iraq. The student was awarded with distinction.