Discussion of a Master’s Thesis
The Department of Life Sciences at the College of Education for Pure Sciences/University of Karbala discussed a master’s thesis entitled (The mutagenic activity of Azithromycin and the protective role of vitamin C in male albino rats), for the student (Hatem Karim Jassab), and under the supervision of Prof. Yasmine Khedir Khalaf and Dr. Alaa Hussein Mahdi. Where the thesis aims to know the effects of the drug on the level of chromosomes and DNA. Knowing the protective role of vitamin C by reducing the side effects of the drug at the genetic, physiological (glutathione, catalase, sodium and potassium ions, liver enzymes (ALT-AST-ALP), urea and creatine) and histologically. And know the effect of the drug Azithromycin on the tissues of the liver and kidney.
The thesis concluded, that the drug caused genetic effects represented by chromosomal abnormalities and DNA degradation, according to the given dose. The protective role of vitamin C in reducing DNA damage and the occurrence of chromosomal abnormalities.
The researcher recommended: Beware of taking large doses of azithromycin, taking vitamins, especially vitamin C when taking antibiotics from the family of microlides, studying the effect of the drug on spleen tissue and cartilage. The student received an honors grade.
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