Discussion of a Master’s Thesis
The Department of Life Sciences at the College of Education for Pure Sciences at the University of Karbala discussed a master’s thesis entitled (Control of the dermal fungus Trichophyton rubrum Microsporum canis using green nano-extracts), by the student (Ghaith Reda Muhammad), and under the supervision of Prof. Ban Taha Muhammad, and Prof. Abbas Matroud Bashi, and the aim of the thesis was to convert plant extracts into nanocomposites for ease of handling, and to study their efficiency and effectiveness in eliminating skin fungi and comparing them with the antifungal fluconazole and plant extracts or creating combinations between them in inhibiting the growth of the two fungi. The study concluded, that the AgcaNps and ZnocaNps hybrid nanocomposites were better than the alcoholic extract of Conocarpus in inhibiting the fungi Trichophyton rubrum and Microsporu canis, and that the AgcaNps and ZnocaNps hybrid nanocomposites were similar to the antifungal Fluconazole compounds in inhibiting the two fungi Trichophyton ruburum synthesis between the two fungi. The hybrid nanocomposites and the antifungal Fluconazole gave greater inhibitory activity than the use of the hybrid nanocomposites, the increase in the synthesis rate between the hybrid nanocomposites and the antifungal Fluconazole led to an increase in the inhibition of the studied fungi, Trichophyton rubrum is less sensitive than Microsporum canis in most treatments.
The discussion resulted in several recommendations, including:
Conducting studies to test the effect of the extracts affecting this study on laboratory animals infected with dermatophytes to determine their suitability for use as therapeutic alternatives and their application to humans, carrying out molecular studies and studying gene expression to determine the location of the effect caused by these plant extracts on fungal cells, conducting studies to purify compounds Effectiveness due to the inhibitory effect on dermatophytes of the most influential plants, the use of combinations of mixing nano-extracts with the antifungal to reduce the recommended dose of the antifungal to reduce its side effects as much as possible. The student received an honors grade.
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