A Scientific Article
The Associate Dean for Scientific Affairs at the College of Education for Pure Sciences, Prof. Dr. (Mohammed Nazem Bahjat) obtained the acceptance to publish a scientific article tagged with the title (Preparation of new smart joint polymeric hydrogels for drug conduction) by the Scientific Articles Committee at the Presidency of the University of Karbala after the fulfillment of all publication conditions. Prof. Dr. Mohamed Nazem Bahgat mentioned that hydrogels are a three-dimensional, hydrophilic polymeric network that has the ability to absorb quantities of water or biological fluids. Because of its high water content, porosity, softness and great consistency, it largely mimics living tissues. More natural than any other type of biological materials manufactured. Hydrogels may be chemically stable or they may degrade and eventually disintegrate and dissolve. They are all prepared from materials such as gelatin, polysaccharides, crosslinked polyacrylic amide polymers, polyelectrolyte complexes, and MMA ester-derived polymers or copolymers. They are all insoluble in water and are available on Solid or wet film form or as wet gel in drug delivery systems designed for single use. In addition, hydrogels can be molded into different physical forms including chips, small particles, nanoparticles, coatings and sheets. As a result, hydrogels are commonly used in clinical practice and medicine with a wide range of applications including tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells and as barrier materials for regulating biological adhesion. These unique physical properties of hydrogels have prompted special interest in their use in drug delivery applications. Their porous structure can easily be tuned by controlling the density of cross-linking in the gel mold and the affinity of the hydrogels with the environment in which they swell. Their porosity allows drug loading into the gel template and drug release depending on the diffusion coefficient. Small molecule or large molecule through the gel network. Because cross-linked polymers cannot dissolve due to cross-linked covalent bonds, they can absorb more water compared to linear hydrophilic polymers. In fact, the benefits of hydrogels for drug delivery may be pharmacokinetics. Specifically, depot structures have been created in which the drug is slowly separated, and to maintain a high topical concentration of the drug in surrounding tissues over a long period of time although it can also be used for systemic delivery. . Hydrogels are generally highly biocompatible materials due to the high water content of the hydrogel, as well as the biodegradability or dissolution in the case of hydrogels can occur by enzyme or hydrolysis or environmental (such as pH, temperature, electric field). Hydrogel T, which has a high water content in addition to the mechanical properties of the tissue, has proven to be able to integrate with tissue engineering cells both in vitro and in vivo. These hydrogels work to deliver the drug to the specific organs, cells or tissues without others, so that the drug performs the therapeutic cycle in the affected places, and also works to supply the affected places with a fixed dose over time, because the hydrogels contain only the required amount of the drug to release the drug only when the cells are found infected. The drug can be inside a layer of hydrogel, or mixed with it to produce different types of drug release systems or the active substance from the hydrogel layer to play its therapeutic role.
To See the Article
